GLP-1 Action and Glucose Tolerance in SubjectsWith Remission of Type 2 DiabetesMellitus After Gastric Bypass Surgery
نویسندگان
چکیده
RESULTSdInfusion of exendin-(9–39) resulted in marginal deterioration of the 2-h plasma glucose after meal intake in RYGBP subjects (saline 78.46 15.1 mg/dL compared with exendin(9–39) 116.5 6 22.3 mg/dL; P , 0.001). Furthermore, glucose response to meal intake was similarly enlarged in the two study groups (percent change in the area under the curve of glucose exendin-(9–39)-infusion versus saline-infusion: controls 10.84 6 8.8% versus RYGBP 9.94 6 8.4%; P = 0.884). In the RYGBP group, the blockade of the enlarged GLP-1 response to meal intake resulted in reduced insulin (P = 0.001) and C-peptide (P , 0.001), but no change in glucagon (P = 0.258) responses.
منابع مشابه
GLP-1 Action and Glucose Tolerance in Subjects With Remission of Type 2 Diabetes After Gastric Bypass Surgery
OBJECTIVE Glucagon like peptide-1 (GLP-1) has been suggested as a major factor for the improved glucose tolerance ensuing after Roux-en-Y gastric bypass (RYGBP) surgery. We examined the effect of blocking endogenous GLP-1 action on glucose tolerance in subjects with sustained remission of type 2 diabetes mellitus (T2DM) present before RYGBP. RESEARCH DESIGN AND METHODS Blood glucose, insulin,...
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